A second pathway of activation of the Torpedo acetylcholine receptor channel
We have studied the interaction of the reversible acetylcholine esterase inhibitor (-)physostigmine (D-eserine)
with the nicotinic acetylcholine receptor (nAChR) from Torpedo marmorata electric tissue by means of ligandinduced
ion flux into nAChR-rich membrane vesicles and of equilibrium binding. We find that (—)physostigmine
induces cation flux (and also binds to the receptor) even in the...
Kehinde O, OKONJO, Jurgen KUHLMANN and Alfred MAELICKE
Okonjo Kehinde » Born 1942. Educated King's College, Lagos (1957-63). BSc, PhD (University of Ibadan). Retired Professor of Chemistry, University of Ibadan. Currently Professor of Chemistry, Covenant University. Current research interests: Kinetics and thermodynamics of reactions of reaction of Ellman's reagent with hemoglobin sulphydryl groups. Publications in such high impact journals as the Journal of... view full profile